Synthesis of β-amino-acid peptides. Part 2. Preparation of peptides of 3-amino-2,2-dimethylpropionic acid by means of conventional coupling reagents and with oxazin-6-one derivatives
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 2468-2471
- https://doi.org/10.1039/p19810002468
Abstract
Side reactions were encountered during the coupling of 3-amino-2,2-dimethylpropionic acid (β-Api) derivatives, some of which could be directly ascribed to steric hindrance at the carboxy-group. Protected and deprotected tri- and hexa-peptides were prepared using dicyclohexylcarbodi-imide and hydroxybenzotriazole. Alternative procedures employing oxazin-6-ones were not as useful as expected.Keywords
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