Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
Open Access
- 1 March 2000
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 82 (5) , 1000-1003
- https://doi.org/10.1054/bjoc.1999.1032
Abstract
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. © 2000 Cancer Research CampaignKeywords
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