A reversible contraceptive action of some 6-chloro-6-deoxy sugars in the male rat

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Abstract
Male rats given daily doses of 240 .mu.mol 6,6''-dichloro-6,6''-dideoxysucrose or 6''-chloro-6''-deoxysucrose or 6-chloro-6-deoxysucrose/kg for 28 days became infertile after 7 days and remained infertile during treatment. Fertility was partly recovered 3 wk after the last dose and completely restored by 6 wk. 6-Chloro-6-deoxyglucose and 6-chloro-6-deoxyfructose were also effective at this dose, but 6,1'',6''-trichloro-6,1'',6''-trideoxysucrose, 4,1'',6''-trichloro-4,1'',6''-trideoxygalactosucrose, 4,6,-4'',6''-tetrachloro-4,6,4'',6''-tetradeoxygalactotrehalose and methyl-6-chloro-6-deoxy-.alpha.-D-glucopyranoside were not. Spermatozoa from the cauda epididymidis of infertile rats oxidized glucose more slowly than did spermatozoa from controls.