In vitroAntiviral Diterpenes from the Brazilian Brown AlgaDictyota pfaffii
- 23 September 2004
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 70 (9) , 856-860
- https://doi.org/10.1055/s-2004-827235
Abstract
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-dihydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude extract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.Keywords
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