Random chromosome changes following SA7 transformation of syrian hamster cells

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Abstract
The chromosome G banding technique was applied to Syrian hamster cells transformed in vitro by the carcinogenic virus SA7 or a combination of polycyclic carcinogenic hydrocarbon and SA7. Chromosome constitution of different clones varied; a normal diploid or an aneuploid constitution with minor structural or numerical deviation was found in some, while in others aneuploidy was associated with increased numerical changes as well as with abnormal chromosomes which are considered as markers. No consistent specific chromosome changes characterized transformation from SA7 or carcinogen pretreatment between the different pools of cells used. Although a lack of consistent chromosome pattern was associated with SA7 viral transformation, the possibility remains that extensive invisible minor genetic changes may have occurred.