Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
Open Access
- 1 October 2005
- journal article
- research article
- Published by Elsevier in Molecular Therapy
- Vol. 12 (4) , 618-633
- https://doi.org/10.1016/j.ymthe.2005.05.006
Abstract
No abstract availableKeywords
This publication has 75 references indexed in Scilit:
- Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal deathNature, 2004
- Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous SystemMolecular Therapy, 2004
- RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxiaNature Medicine, 2004
- Inhibition of polyglutamine aggregate cytotoxicity by a structure‐based elongation inhibitorThe FASEB Journal, 2004
- Loss of normal huntingtin function: new developments in Huntington's disease researchTrends in Neurosciences, 2001
- Recombinant adeno-associated virus purification using novel methods improves infectious titer and yieldGene Therapy, 1999
- Selective and Rapid Uptake of Adeno-Associated Virus Type 2 in BrainHuman Gene Therapy, 1998
- Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansionNature Genetics, 1997
- Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic MiceCell, 1996
- Widespread expression of Huntington's disease gene (IT15) protein productNeuron, 1995