Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells.
Open Access
- 1 October 1983
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 158 (4) , 1356-1361
- https://doi.org/10.1084/jem.158.4.1356
Abstract
Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells. The LAK activation factor was directly and consistently associated with IL-2 activity using classic protein purification techniques, adsorption to IL-2-dependent cell lines, and inhibition with anti-Tac antibody. As yet, no other cytokines have been found that perform the same role.Keywords
This publication has 13 references indexed in Scilit:
- The purification and properties of human T cell growth factor.The Journal of Immunology, 1982
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.The Journal of Immunology, 1981
- In vitro growth of cytotoxic human lymphocytes. III. The preparation of lectin-free T cell growth factor (TCGF) and an analysis of its activity.The Journal of Immunology, 1981
- A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.The Journal of Immunology, 1981
- INVITRO GROWTH OF CYTO-TOXIC HUMAN-LYMPHOCYTES .4. LYSIS OF FRESH AND CULTURED AUTOLOGOUS TUMOR BY HUMAN-LYMPHOCYTES CULTURED IN T-CELL GROWTH-FACTOR1981
- Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.The Journal of Experimental Medicine, 1980
- In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors.The Journal of Immunology, 1980
- Purification of human interleukin 1Journal of Supramolecular Structure, 1980
- Identification of T cell lymphoma tumor antigens on human T cell linesAmerican Journal of Hematology, 1976