An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution
Open Access
- 25 July 2008
- journal article
- research article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 8 (1) , 219
- https://doi.org/10.1186/1471-2148-8-219
Abstract
The origin of nuclear receptors (NRs) and the question whether the ancestral NR was a liganded or an unliganded transcription factor has been recently debated. To obtain insight into the evolution of the ligand binding ability of estrogen receptors (ER), we comparatively characterized the ER from the protochordate amphioxus (Branchiostoma floridae), and the ER from lamprey (Petromyzon marinus), a basal vertebrate.Keywords
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