The Calculation of the Dose to Lymphocytes in External Beam Radiation Therapy

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Abstract
Lymphopenia occurs in patients undergoing external beam radiation therapy when the radiation fields encompass major blood vessels and lymphatic tissue. The dose received by the lymphocytes was previously undefined. A general formalism for the calculation of the lymphocyte dose for a patient undergoing fractionated radiation therapy at an irradiation site is presented. The calculation procedure is demonstrated for a typical case of pelvic irradiation.