Pseudocholinesterase in obesity: Hypercaloric diet induced changes in experimental obese mice
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (11) , 1141-1142
- https://doi.org/10.1007/bf01989883
Abstract
Pseudocholinesterase activity is significantly higher in liver and serum, but lower in adipose tissue of genetically obese, diabetic and gold thioglucose treated mice. Similar enzyme changes were also observed in lean mice on a high carbohydrate diet. A marked reduction (40%) in PChE activity occurred in the liver of genetically diabetic mice when starved for 24 h. These observations suggest that pseudocholinesterase induction in the liver and repression in the adipose tissue is affected by excessive calorie intake in obesity. This provides a model to study the biological function of PChE in health and disease.Keywords
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