Food Intake Depression and Other Metabolic Effects of Tannic Acid in the Rat

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Abstract
The food intake depression and subsequent decrease in growth of rats fed tannic acid was determined at the 4, 5 and 8% level. Pair feeding and supplementation with additional casein, choline or methionine were used to investigate the mechanism of growth depression. Depression of growth occurred due to factors in addition to those which reduce feed intake. No anemia or fatty livers were observed with 5% tannic acid in the diet. Supplementation with choline or methionine had no effect but supplementation with casein improved growth. The toxicity of the tannin decreased with increase in age and weight of rat. Older and heavier rats were able to recover and adjust to tannin in the diet.