THE RÔLE OF DIIODOTYROSINE IN HYPERTHYROIDISM

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Abstract
In a number of publications which appeared recently,1particularly in the German literature, it was reported that the administration of diiodotyrosine to patients with hyperthyroidism causes a striking amelioration of symptoms and a sharp fall in the basal metabolic rate. The response to diiodotyrosine was found to be more marked than that expected with compound solution of iodine (Lugol's solution) and is believed to be not an iodine effect but a specific diiodotyrosine responsesui generis. Remission was obtained with diiodotyrosine in cases refractory to iodides,1eand the need of thyroidectomy could be obviated in less severe cases.1iThese authors regard diiodotyrosine as the medication of choice in the management of hyperthyroidism. However, although a controlled comparison of the effects of diiodotyrosine with the response to more commonly used iodine compounds would seem to be indicated by the therapeutic importance and theoretical interest of these observations, no

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