THE EFFECTS OF TEMPORARY CESSATION OF RENAL BLOOD FLOW IN RATS 1

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Abstract
Complete renal ischemia was produced in rats by clamps which occluded the main renal artery and vein. The ischemia was maintained bilaterally for exact periods of time, i.e., 30 mins., 1 hr., 90 mins., and 2 hrs. and the circulation then restored by removal of the clamps. Rats readily survived a 30-min. period of complete ischemia and usually survived a 1-hr, period. The mortality was high (73%) at 90 mins. and reached 100% at 2 hrs. Animals which died showed progressive elevation of blood urea N and death occurred in uremia from 2-6 days after renal blood flow was restored. In rats which survived, the blood urea N rose to a maximum from 6 hrs. to 3 days after release of the clamps and then declined. The principal morphologic change was necrosis of proximal convoluted tubules, especially the distal or descending segments. Significant damage to epithelium of loops of Henle, and to distal convoluted and collecting tubules as well as to glomeruli, was not morphologically evident. This is in contrast with ''the kidneys of human or exptl. crush syndrome which show lower nephron nephrosis with a lesion involving the ascending loops of Henle and distal convoluted tubules.

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