Teratogenic Evaluation of 2,4,5-T

15 May 1970

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 168 (3933) , 864-866
https://doi.org/10.1126/science.168.3933.864

Abstract

The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in two strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally. The incidences of both cystic kidney and cleft palate were increased in the C57BL/6 mice as well as the incidence of cleft palate in the AKR mice. The incidence of cystic kidney was also increased in the rats. In addition, an increase in the ratio of liver weight to body weight in the mouse fetus and the occurrence of hemorrhagic gastrointestinal tract in the rat fetus suggest that this compound also has fetotoxic properties.

Keywords

This publication has 2 references indexed in Scilit:

Sporadic congenital malformations of newborn inbred mice
Teratology, 1968
The Design and Analysis of Experiments
Soil Science, 1952