Association Between the Tryptophan Hydroxylase Gene and Manic-depressive Illness
Open Access
- 1 January 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 55 (1) , 33-37
- https://doi.org/10.1001/archpsyc.55.1.33
Abstract
THERE IS compelling evidence that abnormalities of serotonergic neurotransmission contribute to depression. The major serotonin (5-hydroxytryptamine [5-HT]) metabolite is 5-hydroxyindoleacetic acid (5-HIAA), and its concentration is low in the cerebrospinal fluid of a subgroup of patients with unipolar depression who attempted suicide by violent means.1,2 Furthermore, platelet 5-HT uptake is diminished in patients with depression3 and especially in patients with bipolar disorder.4,5 Reduced binding of tritiated imipramine or tritiated paroxetine to brain 5-HT uptake sites and transporters has been found in patients with depression6 and in suicide victims.7Keywords
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