Human platelet glycoprotein IX
- 12 November 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 274 (1) , 189-192
- https://doi.org/10.1016/0014-5793(90)81361-q
Abstract
Overlapping cDNAs encoding human platelet glycoprotein (Gp)IX were cloned from a human erythroleukemia cell λ gtll library. The possibly ‘full-length’ cDNA of 896 base pairs (bp) includes an open reading frame (528 bp), both 5' (222 bp) and 3' (146 bp) noncoding regions, and a poly(A) tail. Translation predicts a signal peptide of 16 amino acids and a mature protein of 160 amino acids that includes a 24 amino acid leucinerich glycoprotein (LRG) segment. Southern blot analysis suggests the presence of a single copy of the Gp IX gene, and hybridization of Gp IX cDNA to sorted human chromosomes localizes the Gp IX gene to chromosome 3Keywords
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