Some Agents Which Potentiate the Inotropic Response of the Papillary Muscle to Epinephrine

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Abstract
Cysteine, cystine, tyrosine, ascorbic acid, and plasma potentiate the positive inotropic response of the papillary muscle to epinephrine. The positive inotropic response elicited by BaCl2 is not altered by cysteine, thus suggesting that the general responsiveness of the muscle is not affected by this substance. The amino-oxidase inhibitors, benadryl and indoleacetic acid did not potentiate the epinephrine response. The rate of destruction of the biological activity of epinephrine in the absence of the cardiac tissue is retarded by cysteine and ascorbic acid. The presence of the cardiac tissue appears to have no significant role in the destruction of epinephrine in these expts. The potentiating agents studied will effectively neutralize the blocking action of Cu on epinephrine. The probable mode of action of these potentiating agents is the removal of trace amts. of heavy metals which catalyze the autoxidation of epinephrine.

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