Evidence that the insulin receptor‐associated protein kinase acts as a phosphatidylinositol kinase
- 17 September 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 175 (1) , 113-116
- https://doi.org/10.1016/0014-5793(84)80581-5
Abstract
Insulin receptor preparations from human placenta at various states of purity were shown to catalyze insulin-stimulated phosphate incorporation from [γ-32P]ATP into endogenous (membrane) and exogenous phosphatidylinositol. Our data suggest that the insulin receptor associated protein (tyrosine) kinase can act as a phosphatidylinsositol kinase, and that this mechanism may be of physiological importance in signal transduction of insulin.Keywords
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