Association ofFAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease

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Abstract
AIM: To investigate the association of FAS gene polymorphism with coeliac disease (CD) development. METHODS: FAS-G670A gene polymorphism, located in a gamma interferon activation site, was studied in 146 unrelated CD patients and 203 healthy ethnically matched controls. The restriction fragment length polymorphism (RFLP) method was used to identify FAS-G670A gene polymorphism. RESULTS: No significant difference was found in genotype frequency between CD cases and controls. In controls, however, the frequency of the GG genotype was significantly higher in women (26.5%) than in men (12.8%) (OR = 2.44, 95%CI 1.15-5.20, P = 0.020) and it was also higher in men with CD than controls (OR = 2.60, 95%CI 0.96-7.05, P = 0.061). The GG genotype frequency was significantly higher in patients with most severe villous atrophy (Marsh IIIc lesions) (OR = 3.74, 95%CI 1.19-11.82, P = 0.025). A significantly less proportion of men suffered from Marsh IIIc lesions than women (OR = 0.20, 95%CI 0.06-0.68, P = 0.01). The risk of having severe villous atrophy increased with the additive effect of the G allele in women (P = 0.027 for trend, age and gender adjusted). CONCLUSION: FAS-G670A gene polymorphism is associated with the severity of villous atrophy in CD. Female gender is also associated with the severity of villous atrophy.