Evidence of Free-Radical Activity in Asthma

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Abstract
Oxygen-derived free radicals are highly chemically reactive species capable of widespread indiscriminate tissue injury in biologic systems. Increased systemic production of free radicals is known to be a feature of several inflammatory disorders.1 Since asthma is now known to be an inflammatory disorder of the airways,2 we have looked for evidence of activity of oxygen-derived free radicals in patients with acute severe asthma and stable asthma. We used the diene-conjugated 9,11 isomer of linoleic acid as a marker of free-radical lipid peroxidation.3

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