Improvement in Tardive Dyskinesia After Muscimol Therapy
- 1 May 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 36 (5) , 595-598
- https://doi.org/10.1001/archpsyc.1979.01780050105013
Abstract
• Muscimol, thought to be a agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.Keywords
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