High penetrance, overweight, and glucocorticoid receptor variant: case-control study

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Abstract
All participants lived in or near Sydney and had responded to requests to take part ina study that involved DNA testing. Because of the interaction between obesity and hypertension we selected subjects on the basis of a positive or negative family history of hypertension and tested them separately. Group 1 was recruited from donors at the Sydney BloodBank and comprised 195 subjects who were normotensive offspring of two normotensive parents. Group 2 comprised 124 subjects recruited by public advertising for people with essential hypertension whose parents also had hypertension. Mean body mass index was 26 (SD 4) in group 1 and 26 (SD 5) in group 2; mean age was 48 (SD 10) years and 52 (SD 12) years respectively; percentage of male participants was 57% and 49% respectively; and blood pressure was 120 (SD 11)/73 (SD 8) mm Hg and 173 (SD 24)/110 (SD 17) mm Hg respectively.