Studies on Conditional Gene Expression in the Brain
- 1 April 1999
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 868 (1) , 27-37
- https://doi.org/10.1111/j.1749-6632.1999.tb11271.x
Abstract
This manuscript summarizes our recent attempts to regulate in vitro and in vivo the expression of genes encoding components and regulators of the postsynaptic machinery along with marker genes such as lacZ and GFP. In particular, we studied tTA‐dependent regulation and utilized Cre in combination with reversible silencing by intron engineering of dominant negative alleles. We further present a “knockin” approach for on‐site artificial regulation of chromosomal genes.Keywords
This publication has 21 references indexed in Scilit:
- Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 1996
- Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.Proceedings of the National Academy of Sciences, 1996
- Small-Conductance, Calcium-Activated Potassium Channels from Mammalian BrainScience, 1996
- A mammalian RNA editing enzymeNature, 1996
- Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal deathPublished by Elsevier ,1994
- Cloned Glutamate ReceptorsAnnual Review of Neuroscience, 1994
- Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout micePublished by Elsevier ,1994
- Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targetingCell, 1993
- Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA ReceptorScience, 1992
- The dopamine β-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic miceNeuron, 1991