ADRENAL LIPID AND ALKALINE PHOSPHATASE IN HAMSTERS INFECTED WITH LEISHMANIA DONOVANI

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Abstract
Leishmania infection in hamsters was followed in 4 weeks by an accumulation of lipid and cholesterol in the adrenal cortex normally devoid of these substances. The response was related to the degree of infection. Prolonged stress induced by Leishmania infection alters the morphology of the adrenal cortex sufficiently to suggest adrenal exhaustion as a contributing cause to the death of the animals. The mid-fascicular cells of the normal hamster adrenal contained cytoplasmic alkaline phosphatase. Following infection, the enzyme concn. increased in the adrenal cortex and was distr. in the cytoplasm of the entire fasciculata and reticularis.

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