Chemosensitivity test for carcinoma of digestive organs
- 1 January 1990
- journal article
- research article
- Published by Wiley in Seminars in Surgical Oncology
- Vol. 6 (1) , 42-47
- https://doi.org/10.1002/ssu.2980060109
Abstract
For the chemosensitivity for carcinoma of digestive organs, gastric, colorectal, and hepatic cancer tissues were examined using in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay. The chemosensitivity varied in the tissue. The origin of an organ tumor, histological differentiation, and difference of primary or metastatic lesions are critical for determining chemosensitivity. Biochemical analysis shows that antitumor drugs have an increased susceptibility in tissues with high activity of pyrimidine nucleotide synthesis.Keywords
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