Initiation of Gonadotropin Responsiveness in Hypothalamic Hypogonadism: Comparison of Pulsatile and Continuous Nocturnal Subcutaneous Administration of LH-RH
- 1 May 1983
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 81 (03) , 249-254
- https://doi.org/10.1055/s-0029-1210233
Abstract
An enhanced secretion of LH and FSH was observed in two patients with hypothalamic hypogonadism following treatment with nocturnal s.c. administration of LH-RH. Using portable infusion pumps two forms of therapy were used for 9 nights with a two months interval in between: A) continuous nocturnal s.c. LH-RH; B) pulsatile nocturnal s.c. LH-RH with administration of a bolus dose at 90 min intervals. Both therapeutical regimens induced a rise in the 8:00 h concentrations of LH. The secretory response of LH during an infusion of LH-RH (200 μg i.V.; t = 4 hours) was increased after both forms of therapy, whereas FSH secretion was enhanced only after the pulsatile mode of LH-RH application.Keywords
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