Dietary Resveratrol Does Not Affect Intestinal Tumorigenesis in Apc/+ Mice
Open Access
- 1 January 2004
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 134 (1) , 5-10
- https://doi.org/10.1093/jn/134.1.5
Abstract
To determine its effect on intestinal tumorigenesis and the protumorigenic COX pathway in ApcMin/+ mice, resveratrol was administered as a powdered admixture in the diet at 0, 4, 20, or 90 mg/kg body weight for 7 wk. In two separate experiments, resveratrol did not affect intestinal tumor load. It was stable in the diet under experimental conditions, circulated in the plasma as the glucuronide-conjugated form and reached the tumors as evidenced by significant decreases in PGE2 levels. However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in ApcMin/+ mice.Keywords
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