Description of Age-Depending Cellular Changes in the Human Tonsil

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Abstract
The growth and aging of tonsils was described by means of the behavior of the cell count, T [thymus-derived] cell count, DNA and organ weight. Proliferation of cells and the influx of recirculating T lymphocytes caused hyperplasia up to the age of approximately 17. Later on the cell count and organ weight decreased again. The number of T cells in cell suspensions from the tonsil was lower than that of blood. Due to the proliferation decrease of B [bone marrow derived cells] cells and the accumulation of recirculating T lymphocytes, the T cell count in the tonsil increased with advancing years. The tonsil function decreased as a result of this population shift. No influence of the differentiation of T cells by the tonsil could be detected.

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