A Convenient Synthesis of ?-Acetylenic Acids
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 10 (9) , 653-660
- https://doi.org/10.1080/00397918008065646
Abstract
ω-Acetylenic acids are valuable intermediates in the synthesis of long-chain acids. Their dimagnesium salts may be alkylated with 1-bromo-2-alkynes or 2-alkenes to synthesize many important naturally occurring fatty acids1–3. Also, internally-monounsaturated acids are prepared by alkylation of ω-acetylenic acid dilithium salts4,5 or the sodium salts of their N,N-dimethylamides6.Keywords
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