Effect of short-term bromocriptine treatment on amniotic fluid prolactin concentration in the first half of pregnancy

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Abstract
The effect of short-term bromocriptine treatment on amniotic fluid and maternal prolactin concentrations was studied in 9 pregnant women in the 1st half of pregnancy. Bromocriptine suppressed the maternal serum prolactin level, but had no effect on the amniotic fluid level. Since both fetal and maternal prolactin secretion are suppressed by bromocriptine the results suggest that amniotic fluid prolactin is produced by extrapituitary tissues, which do not contain dopamine receptors.