Design of the Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial [ISRCTN19943732]
Open Access
- 4 December 2000
- journal article
- research article
- Published by Springer Nature in Trials
- Vol. 1 (3) , 184-190
- https://doi.org/10.1186/cvm-1-3-184
Abstract
The Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial is a multicentre,randomised, placebo-controlled trial of magnesium sulphate (MgSO4) funded by the UK Medical Research Council. When complete, it will be the largest single neuroprotective study undertaken to date. Conscious patients presenting within 12 h of acute stroke with limb weakness are eligible. The primary outcome measure is combined death and disability as measured using the Barthel Index at 90-day follow up. By randomizing 2700 patients, the study will have 84% power to detect a 5.5% absolute reduction in the primary end-point. By April 2000, 86 centres were participating, with representation in Canada, USA, Europe, South America, Singapore and Australia. So far, 1206 patients have been randomised, of whom 37% were treated within 6 h. Overall 3-month mortality was 20% and the primary outcome event rate was 43%. The study is ongoing and centres worldwide are encouraged to participate.Keywords
This publication has 25 references indexed in Scilit:
- Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trialThe Lancet, 2000
- Comparison of Retrospective and Prospective Measurements of the National Institutes of Health Stroke ScaleCerebrovascular Diseases, 2000
- Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemiaJournal of Neurosurgery, 1996
- A Comparison of Magnesium Sulfate with Phenytoin for the Prevention of EclampsiaNew England Journal of Medicine, 1995
- A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Intravenous Magnesium Sulfate in Acute StrokeStroke, 1995
- Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2)The Lancet, 1994
- Reduction of Infarct Volume by Magnesium after Middle Cerebral Artery Occlusion in RatsJournal of Cerebral Blood Flow & Metabolism, 1991
- Classification and natural history of clinically identifiable subtypes of cerebral infarctionPublished by Elsevier ,1991
- Interobserver agreement for the assessment of handicap in stroke patients.Stroke, 1988
- Magnesium gates glutamate-activated channels in mouse central neuronesNature, 1984