Studies on the synthesis of lactose by the mammary gland. I. Precursors

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Abstract
The synthesis of lactose from glucose and glycogen by tissue slices of guinea pig mammary gland was demonstrated chromatographi-cally, and an attempt to evaluate the synthesis quantitatively was made by a consideration of the results of 2 entirely unrelated chemical estimations. No lactose synthesis from glucose or glycogen by tissue slices of cow mammary gland could be demonstrated; a critical assessment of previous claims leads to the conclusion that no in vitro demonstration of lactose synthesis by the ruminant gland has yet been made. Maltose (cow and guinea pig glands) and lactate (guinea pig gland) proved ineffective as substrates for lactose synthesis.