Murjne Anti‐Idiotypic Monoclonal Antibodies to Syngeneic Antihuman High Molecular Weight‐Melanoma Associated Antigen Monoclonal Antibodies: Development, Characterization, and Clinical Applications
- 1 December 1988
- journal article
- Published by Wiley in Pigment Cell Research
- Vol. 1 (s1) , 185-191
- https://doi.org/10.1111/j.1600-0749.1988.tb00811.x
Abstract
Following a discussion of the rationale underlying the selection of human melanoma to test the usefulness of anti‐idiotypic monoclonal antibodies in the therapy of solid tumors, the development of the anti‐idiotypic monoclonal antibody MoAb) MF11–30 is described. This antibody recognizes a private idiotope within the antigen‐combining site of the immunizing antihuman high molecular weight melanoma‐associated antigen MoAb 225.28. The results of a phase I clinical trial with the MoAb MF11–30 in patients with advanced melanoma are described. The lack of toxic effects and the minor responses in six patients suggest that these studies should be extended to a larger number of patients with an emphasis on the analysis of the mechanisms underlying the clinical response.Keywords
This publication has 21 references indexed in Scilit:
- A sandwich assay to detect and characterize syngeneic anti-idiotypic antibodies to murine anti-HLA and tumor associated antigen monoclonal antibodiesJournal of Immunological Methods, 1986
- Characterization of melanoma‐associated surface antigens involved in the adhesion and motility of human melanoma cellsInternational Journal of Cancer, 1986
- Phenotypic profile of clones from early cultures of human metastatic melanomas and its modulation by recombinant interferon γInternational Journal of Cancer, 1986
- Human Melanoma Proteoglycan: Expression in Hybrids Controlled by Intrinsic and Extrinsic SignalsScience, 1986
- Antigenic Phenotype of Pigment Cell Lesions: A Study of Melanoma, Its Precursor Lesions and Heterogeneity in Metastatic MelanomaJournal of Investigative Dermatology, 1985
- Recombinant interferon-γ can induce the expression of HLA-DR and -DC on DR-negative melanoma cells and enhance the expression of HLA-ABC and tumor-associated antigensEuropean Journal of Immunology, 1985
- Determination of the immunoreactive function of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excessJournal of Immunological Methods, 1984
- Isolation and chemical characterization of a melanoma-associated proteoglycan antigenArchives of Biochemistry and Biophysics, 1983
- Distribution and molecular characterization of a cell‐surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodiesInternational Journal of Cancer, 1981
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975