Asymmetrische Synthese von L‐γ‐Carboxyglutaminsäure‐Derivaten
- 26 January 1977
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 60 (1) , 43-47
- https://doi.org/10.1002/hlca.19770600107
Abstract
Asymmetric synthesis of L‐γ‐carboxyglutamic acid derivativesA modified Strecker synthesis according to Patel & Worsley was used to prepare γ,γ′‐di‐t‐butyl L(−)‐N‐phthaloyl‐γ‐carboxyglutamate with almost 100% optical purity and an overall yield of about 10% relative to di‐t‐butyl malonate, or 20% relative to (−)‐α‐methyl‐benzylamine (s. Scheme).Keywords
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