The interaction of arylalkylbenzimidazoles and related compounds with microsomal oxidation
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 13 (12) , 707-714
- https://doi.org/10.3109/00498258309052232
Abstract
A series of 2-arylalkyl- and 2-(4''-alkyl)phenoxymethylbenzimidazoles was synthesized and evaluated as inhibitors of mixed-function oxidase activity in phenobarbitone- and .beta.-naphthoflavone-induced rat liver microsomes. Higher homologues of the 2-arylakyl series were more potent inhibitors than lower homologues against all monooxygenase activities except aniline p-hydroxylation. Smaller 2-substituents were associated with relatively low-affinity reverse type 1 spectral binding behavior; larger substituents were associated with type 1 of high affinity binding.This publication has 24 references indexed in Scilit:
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