Erythrodermia, Mycosis fungoides, Skin Reticulosis -Autonomous Disorders of the Monocytopoietic Macrophage System?

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Abstract
Detailed studies of monocytopoiesis and of blood monocytes were carried out in patients with erythrodermia, mycosis fungoides and skin reticulosis. A uniform pattern of several fundamental abnormalities was evaluated: (1) excessive monocytopoietic hyperproliferation focusing on promonocytes which exhibited lymphocyte size; (2) premature monocyte release from the bone marrow into the blood; (3) marked increase of pyknotic monocytes circulating, and (4) frequent occurrence of blood leukocytes which were characterized by large round nuclei, absence of NaF sensitive esterase and high DNA synthesis activity. There was some evidence indicating that these cells represent promonocytes with low degree of cytoplasmatic differentiation. This pattern of monocytopoietic abnormalities was uniformly present in virtually all patients. It did not correlate with the clinical diagnosis or with the extent of skin lesions

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