Association Between HIV-1 Infection, the Etiology of Genital Ulcer Disease, and Response to Syndromic Management

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Abstract
Reports on the effect of HIV-1 infection on healing rates of ulcers are conflicting. The goal was to determine the etiology and response to treatment of genital ulcer disease (GUD) in relation to HIV-1 infection. This was a cohort study of patients with GUD treated with local syndromic management protocols. Among the 587 recruited, the prevalences of infections due to HSV, Treponema pallidum, Chlamydia trachomatis (lymphogranuloma venereum [LGV]), Haemophilus ducreyi, Calymmatobacterium granulomatis, and HIV-1 were 48%, 14%, 11%, 10%, 1%, and 75%, respectively. The prevalence of T pallidum was higher among men (P = 0.03), and an association was seen among HIV-1-seronegatives on univariate and multivariate analyses (P P Response to syndromic management of GUD was acceptable and not associated with HIV-1 coinfection.