The Dose and Duration of Effect of Levocabastine, A New Topical H1 Antagonist, on Nasal Provocation Reaction to Allergen

Publisher Website
Google Scholar
Abstract
This study investigated the dose and duration of effect of topical levocabastine (LC) in patients with perennial allergic rhinitis as evaluated by the effect on nasal provocation test with house dust antigen. Three different doses (0.05, 0.1, and 0.2 mg) of LC were independently administered to evaluate the dose response and duration of effect. Reaction to nasal provocation was evaluated by a scoring system based on a combination of symptoms, such as number of sneezes, degree of nasal discharge, and nasal obstruction. The mean scores at 30 minutes postadministration of each of the three different doses of LC showed a significant decrease as compared with those of preadministration. The effect persisted for 4 hours with a dose of 0.05 mg and 0.1 mg of LC and for 12 hours with 0.2 mg of LC. In a comparison of the three doses potency of effect of LC, the highest dose (0.2 mg) demonstrated the strongest effect in the interval from 4 hours to 10 hours postadministration. These results indicate that LC has an immediate effect and its effect is dose dependent. The present study suggests that nasal symptoms in perennial allergic rhinitis could be relieved by topical application of 0.2 mg of LC, twice a day.