Overexpression of glutathione reductase extends survival in transgenicDrosophila melanogasterunder hyperoxia but not normoxia
- 1 October 1999
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 13 (13) , 1733-1742
- https://doi.org/10.1096/fasebj.13.13.1733
Abstract
The purpose of this study was to test the hypothesis that overexpression of glutathione reductase in transgenic Drosophila melanogaster increases resistance to oxidative stress and retards the agin...Keywords
Funding Information
- National Institute on Aging (RO1 AG7657)
- National Institutes of Health (RO1 AG15122)
This publication has 35 references indexed in Scilit:
- Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogasterPublished by Elsevier ,2003
- Kinetic studies on the removal of extracellular tert-butyl hydroperoxide by cultured fibroblastsBiochimica et Biophysica Acta (BBA) - General Subjects, 1995
- Inhibition of glutathione-related enzymes and cytotoxicity of ethacrynic acid and cyclosporineBiochemical Pharmacology, 1995
- Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogasterScience, 1994
- Oxidized Redox State of Glutathione in the Endoplasmic ReticulumScience, 1992
- Protein Oxidation and AgingScience, 1992
- The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogasterArchives of Biochemistry and Biophysics, 1992
- Reduced glutathione in combination with superoxide dismutase as an important biological antioxidant defence mechanismBiochemical Pharmacology, 1989
- Enhanced oxygen toxicity following treatment with 1,3-bis(2-chloroethyl)-1-nitrosoureaFundamental and Applied Toxicology, 1984
- Transposition of Cloned P Elements into Drosophila Germ Line ChromosomesScience, 1982