Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes
Open Access
- 3 July 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (2) , 622-624
- https://doi.org/10.1016/0014-5793(89)80809-9
Abstract
Lectin stimulation of human T lymphocytes causes a 7‐fold increase in the specific activities of GTP‐cyclohydrolase and a 4‐fold increase in the specific activities of sepiapterin reductase. GTP‐cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities continue to increase during the 72 h period measured. The specific activities of 6‐pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP‐cyclohydrolase and sepiapterin reductase.Keywords
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