Bronchial Hypersensitivity to Methacholine in Monkeys with Beta-Adrenergic Blockade

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Abstract
In monkeys with beta-adrenergic blockade caused by administration of propranolol, we found that the conductance of the total respiratory system markedly decreased following intravenous administration of methacholine. The presence of beta-adrenergic blockade was judged from inotropic effect on the heart, levels of blood glucose and lactic acid, and the reaction of eosinophils after adrenalin injection.
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