The Strain of Mouse and Assay Conditions Influence Whether MulFN- γ Primes or Activates Macrophages for Tumor Cell Killing

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Abstract
Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MulFN- γin macrophage activation. The findings suggest that the capacity of MulFN- γto activate macrophages without the need for a second triggering stimulus is related to assay conditions and, most especially, the strain of mouse used to provide the macrophages.

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