Site of Action of Chlorsulfuron

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Abstract
The sulfonylurea herbicide chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Addition of these 2 amino acids to excised pea root (Pisum sativum L. cv. Alaska) cultures incubated in the presence of chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of chlorsulfuron is the enzyme acetolactate synthase which catalyzes the 1st step in the biosynthesis of valine and isoleucine. This enzyme is extremely sensitive to inhibition by chlorsulfuron having I50 values ranging from 18-36 nM. Acetolactate synthase from a wide variety of tolerant and sensitive plant species is highly sensitive to inhibition by chlorsulfuron.

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