LEUKOTRIENES C4 AND D4 INDUCE PROSTAGLANDIN AND THROMBOXANE RELEASE FROM RAT PERITONEAL MACROPHAGES
Open Access
- 1 March 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 72 (3) , 389-391
- https://doi.org/10.1111/j.1476-5381.1981.tb10988.x
Abstract
The present study examined the effect of leukotrienes C4 and D4, the products of the 5′ lipoxygenase pathway on prostaglandins and thromboxane release from rat peritoneal macrophages. Incubation of rat peritoneal macrophages with leukotrienes C4 and D4 enhanced the release of prostaglandin E2 (PGE2), 6-keto PGF1α and thromboxane B2 (TxB2) in a dose-dependent manner. The increase of PGE2 was more pronounced than that of 6-keto-PGF1α and TxB2. Lipopolysaccharide, a known stimulator of these cells elicited a similar pattern of increase of the arachidonate metabolites assayed. These results suggest that leukotrienes C4 and D4 are potential activators of macrophages. Since leukotrienes C4 and D4 are produced by these cells, it is suggested that endogenous leukotrienes may be involved in activation of macrophages.Keywords
This publication has 11 references indexed in Scilit:
- The synthesis of a leukotriene with SRS-like activityTetrahedron Letters, 1980
- Parallel inhibition of neutrophil arachidonic acid metabolism and lysosomal enzyme secretion by nordihydroguaiaretic acidLife Sciences, 1980
- Mouse peritoneal macrophages release leukotriene C in response to a phagocytic stimulus.Proceedings of the National Academy of Sciences, 1980
- Regulation of arachidonic acid metabolites in macrophages.The Journal of Experimental Medicine, 1980
- Leukotrienes and Slow Reacting Substance of Anaphylaxis (SRS‐A)Allergy, 1980
- Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sourcesProceedings of the National Academy of Sciences, 1980
- Monohydroxyeicosatetraenoic acids (HETEs) induce degranulation of human neutrophils.The Journal of Immunology, 1980
- Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function.1980
- Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme releaseBiochemical Journal, 1979
- Radioimmunoassays for prostaglandin metabolites.1976