COWS MILK PROTEIN-SENSITIVE ENTEROPATHY - CLINICAL AND HISTOLOGICAL RESULTS OF THE COWS MILK PROVOCATION TEST

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 34  (4) , 309-318
Abstract
Nineteen infants suspected of having cow''s milk protein-sensitive enteropathy were studied. They all showed failure to thrive, diarrhea and/or vomiting when fed a diet of cow''s milk and improved when their diet was changed to casein hydrolysate. Jejunal biopsy was done before and 18-23 h after a milk challenge. Of 19 infants, 12 presented histological evidence of cow''s milk protein intolerance. Eight suffered from vomiting and diarrhea within 9 days of the milk challenge, but in 4 cases the histological abnormalities were not accompanied by clinical symptoms. In 1 case a chicken meat intolerance was documented. The histological appearance of the intestinal mucosa after chicken challenge was identical to that observed after milk challenge. Repeated intestinal biopsies before and after an acute challenge is the best method to establish the diagnosis not only of cow''s milk protein intolerance, but also of intolerance to other alimentary proteins.

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