Fibrinolysis, Fibrinogen and Thrombin Time in Newborns

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Abstract
Comparative experiments were made on blood samples collected with and without addition of a potent fribrinolysis-blocking agent in newborn infants aged up to 12 h. Prevention of the in vitro fibrinolysis resulted in a diminished frequency of an abnormal euglobulin clot lysis time, but there was no significant difference in fibrinogen levels and in the frequency and degree of a prolonged thrombin time. These results indicate that the prolongation of thrombin time in newborn infants cannot be prevented by blocking the in vitro fibrinolysis. The significance of these findings is discussed with regard to the possible existence of an abnormal ‘fetal fibrinogen’.

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