Actions of levodopa on the blood pressure of conscious rabbits
Open Access
- 1 June 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 48 (2) , 194-197
- https://doi.org/10.1111/j.1476-5381.1973.tb06905.x
Abstract
1 . In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg. 2 . After inhibition of monoamine oxidase, levodopa induces a sustained pressor response. 3 . This response can be blocked by inhibition of extracerebral decarboxylase. 4 . Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.Keywords
This publication has 7 references indexed in Scilit:
- Cardiovascular and renal actions of dopamine: potential clinical applications.1972
- Effects of dopamine on the conductance of perfused vascular beds of the chloralosed catBritish Journal of Pharmacology, 1972
- New evidence for an α-adrenergic component in the sympathetic centres: Centrally mediated decrease in sympathetic tone by 1-dopa and its antagonism by piperoxane and yohimbineEuropean Journal of Pharmacology, 1972
- The cardiovascular pharmacology of L(--)-dopa: peripheral and central effects.1971
- Modification of the Cardiovascular Effects of L -Dopa in Anesthetized Dogs by Inhibitors of Enzymes Involved in Catecholamine MetabolismCirculation Research, 1971
- Influence of pargyline on the effects of dopamine infusions on sympathetically innervated tissuesNeuropharmacology, 1970
- Evidence for a centrally mediated hypotensive effect of L-dopa in the ratJournal of Pharmacy and Pharmacology, 1970