PROGNOSTIC CHARACTERISTICS OF SERUM HUMAN CHORIONIC-GONADOTROPIN TITER REGRESSION FOLLOWING MOLAR PREGNANCY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (4) , 478-482
Abstract
The postevacuation serum .beta. human chorionic gonadotropin (hCG) regression curves of 77 women with hydatid moles were analyzed from the perspective of refining the criteria for diagnosis of gestational trophoblastic neoplasia. Patients (49, 64%) demonstrated a spontaneous, progressive fall in serum hCG titers to levels nondetectable by radioimmunoassay within 15 wk. The regression curves of the remaining 28 patients exhibited a plateau or rise in titer, usually during the first 6 wk after evacuation. Analysis of the 2 groups demonstrates a statistically signficant difference in regression curves that permits early identification of the patient with gestational trophoblastic neoplasia. The significance of these curves is discussed.

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