PLASMA, RED-CELL AND CEREBROSPINAL-FLUID CONCENTRATIONS OF MANNITOL AND SORBITOL IN PATIENTS WITH SEVERE CHRONIC RENAL-FAILURE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 8  (6) , 368-373
Abstract
The concentrations of mannitol and sorbitol in plasma, red cells, CSF and urine were determined in 24 patients with chronic renal failure; 10 of them were on conservative treatment and 14 were hemodialyzed 3 times/wk. The mannitol concentration was significantly increased in the plasma and the CSF of the uremic patients compared with the controls. In 6 out of 10 uremic patients mannitol clearance values exceeded creatinine clearance values. The plasma concentration of sorbitol was undetectable or very low in all patients and control subjects. Red-cell and CSF concentrations of sorbitol showed a large individual variation in the uremic patients on conservative treatment and did not correlate with kidney function. During dialysis the mannitol concentration decreased, leading to a small osmotic gradient between the plasma and the red cells. The changes in the concentration of mannitol during dialysis showed no connection with the symptoms of central nervous disturbance which appeared during dialysis treatment. The red cell sorbitol concentration during dialysis increased by about 20%. There was a correlation (P < 0.05) between the increase in sorbitol in CSF and signs of peripheral neuropathy in the conservatively treated uremic patients.

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