Relative bioavailability of oral low dose methotrexate
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 34 (5) , 517-519
- https://doi.org/10.1007/bf01046713
Abstract
In 39 patients the bioavailability of methotrexate from the two tablets Emthexat 2.5 mg and Methotrexate 2.5 mg was assessed in a double-blind study after a single oral dose of 30 mg/m2 Methotrexate. There was a considerable inter-individual variation of the serum pharmacokinetics in regard to Cmax and tmax, independent on the MTX formulation. Emthexat 2.5 mg tablets and Methotrexate 2.5 mg tablets were bioequivalent according to the definition (AUCE≥AUCM×80%).This publication has 12 references indexed in Scilit:
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